Antibodies Research Blog

Die Firma Antikörper-Online hat nun auch eine französische Internetseite. Wenn ihr mögt, dann schaut doch einfach mal rein.

http://www.anticorps-enligne.fr/

Stellenangebote für Krankenschwestern, Pfleger und andere medizinisch orientierte Berufe finden sich in großer Anzahl auf der neuen Stellenplattform www.krankenhaus-stellen.de. Suchende können sich hier ein Profil samt Lebenslauf zusammenstellen und sich direkt über die Plattform bei interessanten Stellen bewerben. Das Ganze ist komplett kostenlos. Anmelden und reinschauen lohnt sich also auf jeden Fall einmal. Das Unternehmen wurde 2010 frisch als Startup der RWTH Aachen gegründet und hat sich zum Ziel gesetzt, stellensuchende Ärzte, MTA, PTA und alle anderen Berufszweige direkt und ohne Mittler mit den ausschreibenden Krankenhäusern zusammenzubringen.

E. coli is still the most widely used production system for recombinant antibodies. An alternative to time-and cost-hybridoma technique provides the phage display technology. It comes complete without immunization, and thus without the use of laboratory animals. It is suitable for selection of highly specific recombinant AK fragments and identification of epitopes in vitro, ie outside the living organism. Besides the use of prokaryotes for the production of recombinant antibodies is intensively investigated in further production. Especially possibilities are currently being investigated, such as plants make use of it.

Recombinant therapeutic antibodies

Attempts to use recombinant antibodies for therapeutic purposes were at first only partially successful. In many cases, they identified themselves as antigens to attack by the organism. This problem has been solved in many application areas by managed to adapt the antibody fragments to the organism (humanizing). Here has also established the concept of antibody engineering, can imagine the effect that it is in the adaptation of recombinant antibodies with the desired properties is now more a scientific engineering approach as a classical biological. There are concepts, such as affinity maturation, humanization, design of fusion proteins, increase production yields for the language. Recombinant antibodies are very promising and come in more and more areas of medicine are used. There is already a wide range of worldwide and also in Germany, licensed, recombinant antibodies. This, the site provides an overview of the investigators pharmaceutical companies in Germany. The range of applications approved recombinant antibodies now stretches from the diagnosis and / or antibodies therapy of various cancers, the treatment of multiple sclerosis, asthma and Alzheimer’s disease. Especially in the treatment of the latter is in relation to the use of recombinant antibodies of intensive research.